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Internal Medicine

The all-shelves Internal Medicine map. Every published Bone Wizardry deep-dive, organized by clinical system and ordered by exam weight, high to low. The high-yield topics still missing are tracked under each system as the build queue.

Across every system, the exam keeps testing the same physician tasks: History & Physical / Diagnosis (25-30%), Diagnostic Technologies (25-30%), Management (20-30%), Health Promotion & Prevention (5-10%), and Scientific Mechanisms (10-20%). The pages below cover all five; jump to Read the Test for the diagnostic-technologies rail.

New · Build in progress Prevention & Screening USPSTF cancer screening, adult immunizations, and health maintenance by age. The biggest blueprint gap, built first.
01

Cardiovascular & Circulatory

COMAT 16-22%
Heart MurmursFree
Cardio · Valvular
Mitral RegurgitationPro
Cardio · Valvular
Diastolic RumblePro
Cardio · Valvular
Wide S2 SplitPro
Cardio · Heart sounds
Paradoxical S2 SplitPro
Cardio · Heart sounds
CardiomyopathiesFree
Cardio · Myocardial
Frank-Starling MechanismFree
Cardio · Mechanism
HemodynamicsPro
Cardio · Mechanism
Inferior MI + AV BlockPro
Cardio · ACS
Post-MI Complications TimelinePro
Cardio · ACS
MI ED Meds: MONA-BAHPro
Cardio · ACS management
AntiarrhythmicsFree
Cardio · Arrhythmia mgmt
Lead I EKGPro
Cardio · Dx tech
Beta-BlockersPro
Pharm · HTN / IHD mgmt
DigoxinFree
Pharm · Rate / CHF mgmt
Renal Artery Stenosis & RAASFree
Renal · Secondary HTN
Cholesterol Synthesis & RegulationPro
Biochem · Hyperlipidemia

Gaps · build nextPrimary hypertension (staging + management) · aortic dissection · infective endocarditis (Duke criteria) · pericarditis / tamponade · peripheral arterial disease · atrial fibrillation (CHADS-VASc, rate vs rhythm) · hyperlipidemia / ASCVD targets · aortic stenosis as a standalone page.

02

Respiratory

COMAT 16-22%
Asthma vs COPDFree
Resp · Obstructive
PneumoniasFree
Resp · Infection
Lung AbscessFree
Resp · Infection
PE & DVTFree
Resp · Vascular
ARDSFree
Resp · Critical care
Acid-Base & ABGsFree
Resp · Dx tech
Pulm Physiology HubFree
Resp · Mechanism
SarcoidosisFree
Resp · Interstitial
Lung CancersFree
Resp · Oncology

Gaps · build nextOccupational / environmental lung disease (asbestosis, silicosis) · pleural effusion / pneumothorax · obstructive sleep apnea · TB clinical · pulmonary hypertension · bronchiectasis / adult cystic fibrosis.

03

Heme / Onc / Immunology

COMAT 13-18%
AnemiasFree
Heme · Hub
Microcytic AnemiasFree
Heme · Anemia
Macrocytic / Normocytic & PNHFree
Heme · Anemia
Iron Deficiency WorkupFree
Heme · Dx tech
Lead PoisoningFree
Heme · Toxic
Coagulation & Bleeding DisordersFree
Heme · Coagulation
Coagulation CascadeFree
Heme · Mechanism
Hemophilia & Coag CascadePro
Heme · Coagulation
Platelet DisordersPro
Heme · Coagulation
Drugs of the Clotting CascadePro
Heme · Management
Multiple Myeloma & MGUSFree
Heme · Malignancy
Chromosomal TranslocationsFree
Heme · Malignancy
Hypersensitivity I-IVFree
Immuno · Allergy
Autoantibodies & Drug-Induced LupusFree
Immuno · Dx tech
Primary ImmunodeficiencyPro
Immuno · Immunodeficiency
VasculitidesPro
Immuno · Vasculitis
Opportunistic Infections · CD4 LadderFree
Micro · HIV / AIDS
Antimetabolites & Drug InteractionsFree
Pharm · Chemo
Cancer PathologyFree
Path · Neoplasm
Where Cancer LandsFree
Path · Metastasis
Oncogenes & Tumor SuppressorsFree
Path · Mechanism
The Psammoma ClubFree
Path · Solid tumor
The Cancer CascadeFree
Path · Radiation

Gaps · build nextHIV clinical (Dx / ART / staging) · anaphylaxis acute management · hypercoagulable states / VTE workup (Factor V Leiden, antiphospholipid) · sickle cell disease clinical / crises · transfusion reactions · tumor lysis & oncologic emergencies · myeloproliferative neoplasms (PV, CML clinical).

04

GI & Nutrition

COMAT 12-16%
Crohn's vs UCFree
GI · IBD
Hepatitis SerologiesFree
GI · Liver / Dx tech
The Liver's Hit List (HCC)Free
GI · Liver
Liver MetastasesFree
GI · Liver
PSC vs PBCFree
GI · Biliary
Pancreas Eats ItselfFree
GI · Pancreas
PPI-Induced HypergastrinemiaPro
GI · Upper GI
Zinc DeficiencyPro
GI · Nutrition
Wernicke + KorsakoffPro
Neuro · Thiamine deficiency

Gaps · build nextGERD · peptic ulcer disease / H. pylori · cirrhosis & portal hypertension (varices, ascites, hepatic encephalopathy, SBP) · alcoholic / NAFLD-NASH hepatitis clinical · cholecystitis / cholangitis / choledocholithiasis · diverticular disease · GI bleed approach · malabsorption / celiac · colorectal cancer screening.

05

Nervous System & Mental Health

COMAT 8-12%
Stroke SyndromesFree
Neuro · Stroke
Cortical Stroke SyndromesPro
Neuro · Stroke
Brainstem Stroke SyndromesPro
Neuro · Stroke
Lenticulostriate StrokesPro
Neuro · Stroke
Intracranial HemorrhagesPro
Neuro · Stroke
DementiasFree
Neuro · Neurodegenerative
Parkinson DiseasePro
Neuro · Neurodegenerative
Movement DisordersPro
Neuro · Movement
Demyelinating DiseasesFree
Neuro · Demyelinating
NMJ DisordersFree
Neuro · Neuromuscular
Spinal StenosisPro
Neuro · Spinal cord
Seizures & EpilepsyPro
Neuro · Cerebral
Idiopathic Intracranial HypertensionPro
Neuro · Cerebral
Cranial Nerve LesionsFree
Neuro · Peripheral
Schizophrenia & Mood DisordersFree
Psych · Mental health
The Mood Map: AntidepressantsFree
Psych · Management
Antipsychotics, Mood Stabilizers & AnxiolyticsFree
Psych · Management
Cluster A Personality DisordersFree
Psych · Mental health
Code Gray: The Agitated PatientFree
Psych · Management

Gaps · build nextPeripheral neuropathy (diabetic / GBS) · meningitis & encephalitis clinical · delirium vs dementia workup · migraine vs tension vs cluster management · Bell's palsy / mononeuropathies.

06

Genitourinary / Renal

COMAT 5-10%
AKI vs CKDFree
Renal · AKI / CKD
Nephrotic vs NephriticFree
Renal · Glomerular
RTA Deep DiveFree
Renal · Tubular
Electrolyte DisordersFree
Renal · Fluid / lytes
Renal Artery Stenosis & RAASFree
Renal · Vascular
Diuretic Sites & ToxicityPro
Renal · Management
Prostate Cancer DrugsFree
Pharm · GU oncology

Gaps · build nextUTI / pyelonephritis clinical · nephrolithiasis (stone types, workup) · BPH & obstructive uropathy · urinary incontinence · testicular torsion / epididymitis / testicular cancer · prostatitis.

07

Endocrine & Metabolism

COMAT 5-7%
DKA vs HHSFree
Endo · Diabetes
Insulinoma & Hypoglycemia WorkupFree
Endo · Diabetes
Antidiabetic Drug ClassesPro
Pharm · Management
Thyroid DisordersFree
Endo · Thyroid
Calcium, PTH & Vitamin D AxisFree
Endo · Parathyroid
Adrenal InsufficiencyPro
Endo · Adrenal
Adrenal AdenomasFree
Endo · Adrenal
Congenital Adrenal HyperplasiaFree
Endo · Adrenal
Pituitary Tumors, SIADH & DIFree
Endo · Pituitary
Gigantism (GH Excess)Free
Endo · Pituitary
MEN SyndromesFree
Endo · Tumor syndrome
The Pancreatic VillainsFree
Endo · Islet tumors
GlucagonomaFree
Endo · Islet tumors
Hypothalamic & Pituitary DrugsFree
Pharm · Management

Gaps · build nextThyroid storm / myxedema coma · hyperparathyroidism clinical (primary vs secondary) · obesity / metabolic syndrome · chronic diabetes complications & screening (retinopathy, nephropathy, neuropathy).

08

MSK & Rheumatology

COMAT 5-7%
The Big 5 Autoimmune DiseasesFree
MSK · Inflammatory
The Spondyloarthropathy QuartetPro
MSK · Seronegative
Autoantibodies & Drug-Induced LupusFree
Immuno · Rheum serology
VasculitidesPro
Immuno · Vasculitis
Viscerosomatic ReflexesFree
OMM · Viscerosomatic
Low Back PainFree
OMM · Somatic dysfunction

Gaps · build nextGout / pseudogout (crystal arthropathy) · osteoarthritis vs RA clinical · osteoporosis (DEXA / T-score / bisphosphonates) · polymyalgia rheumatica / giant cell arteritis · fibromyalgia · septic arthritis / osteomyelitis · poly- and dermatomyositis.

09

Integumentary

COMAT 5-7%
Classic Derm FindingsFree
Derm · Lesions
Skin CancersFree
Derm · Oncology
Actinic KeratosisFree
Derm · Precancer
Hypersensitivity I-IVFree
Immuno · Atopic mechanism

Gaps · build nextAtopic dermatitis / eczema · psoriasis · contact dermatitis · cellulitis & bacterial skin infections · bullous diseases (pemphigus / pemphigoid) · drug eruptions / SJS-TEN · acne / rosacea.

10

Community Health & Prevention

COMAT 5-7%
Prevention & ScreeningFree
IM · New module
Sensitivity, Specificity & Study DesignFree
Biostats · Screening principles
Medical Interpreter RulesFree
Biostats · Communication
Medication AdherenceFree
Endo · Behavioral

Gaps · build nextUSPSTF cancer screening schedule (breast, cervical, colon, lung, AAA, prostate) · adult immunization schedule · smoking cessation counseling · preventive cardiology (lipid & HTN screening) · health maintenance by age. Most of these land in the new Prevention & Screening module above.

🔎

Read the Test

Dx Tech 25-30%

Diagnostic Technologies is the single heaviest physician task on the shelf. These pages cut across every system: the EKG, the ABG, the LFTs, the CBC, and the serology that the vignette hands you.

Acid-Base & ABGsFree
Read the ABG
Iron Deficiency WorkupFree
Read the CBC / iron studies
Hepatitis SerologiesFree
Read the serology panel
AutoantibodiesFree
Read the rheum panel
Lead I EKGPro
Read the tracing
Sensitivity, Specificity & Study DesignFree
Interpret the test

Gaps · build nextFull 12-lead EKG interpretation · LFT pattern reading (AST/ALT ratio, cholestatic vs hepatocellular) · chest X-ray approach · urinalysis & urine sediment.

This hub links only pages already published in Bone Wizardry. Topics under each Gaps · build next line are on the build queue. Browse by subject · COMLEX Study Path · Home.