Study Hub

Neurology

Neurology rewards the student who localizes before diagnosing: place the deficit on the map (cortex, tract, vessel, junction, or muscle), then name the one finding that fixes it and the next step. Every Bone Wizardry neuro deep-dive, organized by system and stacked by yield.

Roughly two thirds of items are vignette diagnosis and management (lesion localization, next best test, acute versus preventive treatment), with the DO exam leaning harder on primary-care management and osteopathic options for cervicogenic headache, radiculopathy, and post-concussion care.

01

Cerebrovascular Disease and Stroke

Yield 14-18%
Acute Ischemic Stroke
Neuro · tPA, thrombectomy, BP
Stroke Syndromes
Neuro · Vascular territory map
Cortical Stroke Syndromes
Neuro · ACA, MCA, PCA
Brainstem Stroke SyndromesPro
Neuro · Wallenberg, Weber, locked-in
Lacunar StrokesPro
Neuro · Pure motor, pure sensory
Intracranial HemorrhagesPro
Neuro · Epidural to SAH
Charcot-Bouchard Aneurysm
Neuro · Hypertensive bleed
Aphasia Types
Neuro · Broca, Wernicke, conduction
Cerebral Cortex LocalizationPro
Neuro · Lobes and function map
Atrial Fibrillation and CardioembolismPro
Cardio · Anticoagulation, CHA2DS2-VASc
02

Headache and Facial Pain

Yield 10-13%
Headache Differentials
Neuro · Migraine, cluster, tension
Idiopathic Intracranial HypertensionPro
Neuro · Pseudotumor, papilledema
Giant Cell Arteritis and VasculitisPro
Immuno · Temporal arteritis, ESR
Cervical Spine OMM
OMM · Cervicogenic headache
03

Seizures and Epilepsy

Yield 8-10%
Seizures and EpilepsyPro
Neuro · Focal vs generalized
Alcohol and Substance Withdrawal
Psych · Withdrawal seizures, DTs
Sodium and Osmolality Disorders
Renal · Hyponatremia, osmotic demyelination
Eclampsia and HELLP
Repro · Seizure in pregnancy, magnesium
04

Neuromuscular and Demyelinating Disease

Yield 14-18%
Demyelinating Disease
Neuro · MS, central vs peripheral
Guillain-Barre Syndrome
Neuro · Ascending, areflexic, IVIG
NMJ Disorders
Neuro · Myasthenia vs Lambert-Eaton
ALSPro
Neuro · UMN plus LMN signs
Botulism
Micro · Descending paralysis, toxin
Autonomic Failure
Neuro · Orthostatic hypotension
Thoracic Outlet Syndrome
MSK · Brachial plexus compression
Brachial Plexus and UE Nerves
OMM · Plexus and entrapment
Lower Extremity Nerve Injuries
OMM · Sciatic, peroneal, femoral
Femoral Nerve and SpasticityPro
Neuro · Hip flexor, mononeuropathy
05

Movement Disorders

Yield 7-9%
Parkinson DiseasePro
Neuro · TRAP, Lewy bodies
Huntington DiseasePro
Neuro · CAG repeats, chorea
Movement Disorders OverviewPro
Neuro · Tremor, chorea, myoclonus
Wilson DiseasePro
Neuro · Copper, Kayser-Fleischer
Basal Ganglia CircuitryPro
Neuro · Direct vs indirect pathway
Restless Legs SyndromePro
Neuro · Iron and dopamine
Dopamine PathwaysPro
Neuro · Drug-induced parkinsonism
06

Dementia and Delirium

Yield 7-9%
Dementias
Neuro · Alzheimer, Lewy, FTD
Neurodegeneration Decoder
Neuro · Protein, pattern, disease
Normal Pressure Hydrocephalus
Neuro · Wet, wacky, wobbly
Wernicke-KorsakoffPro
Neuro · Thiamine before glucose
HIV-Associated DementiaPro
Neuro · Subcortical, late HIV
Drug-Induced Mental StatusPro
Pharm · Delirium and tremor
07

CNS Infections

Yield 6-8%
Meningitis
Micro · CSF by age and cause
HIV Opportunistic Infections
Micro · Toxo, PML, crypto by CD4
NeurosyphilisPro
Micro · Tabes dorsalis, Argyll Robertson
08

Neuro-oncology, ICP and Hydrocephalus

Yield 4-6%
Brain TumorsPro
Neuro · Adult primary and mets
Pituitary Tumors, SIADH and DI
Endo · Bitemporal hemianopia
MedulloblastomaPro
Neuro · Posterior fossa, kids
Pilocytic AstrocytomaPro
Neuro · Rosenthal fibers
Craniopharyngioma
Neuro · Rathke pouch, calcified
EpendymomaPro
Neuro · Fourth ventricle
09

Cranial Nerves, Vision and Vertigo

Yield 7-9%
Cranial Nerve Lesions
Neuro · All 12 localized
Extraocular Muscles and Gaze Palsies
Neuro · CN III, IV, VI
Bell Palsy
Neuro · Peripheral CN VII
Peripheral Vertigo and BPPV
Neuro · HINTS, Dix-Hallpike, Epley
Cribriform Plate and CN IPro
Neuro · Anosmia from trauma
Olfactory Nerve Trauma
Neuro · CN I shearing injury
Maxillary Dental Innervation
Anatomy · Trigeminal CN V2 sensory branches
10

Spine, Radiculopathy and Neurotrauma

Yield 7-9%
Spinal Cord SyndromesPro
Neuro · Brown-Sequard and more
Conus Medullaris vs Cauda EquinaPro
Neuro · The surgical emergency
Cervical Radiculopathy
Neuro · C5 to T1 localization
Sciatica Localizer
Neuro · Lumbar nerve root
Spinal StenosisPro
Neuro · Neurogenic claudication
Spinal TractsPro
Neuro · DCML, spinothalamic, corticospinal
Low Back Pain and OMT
OMM · Red flags and treatment
Piriformis Syndrome
OMM · Deep gluteal sciatic nerve entrapment
11

Pediatric and Neurogenetic Disorders

Yield 4-6%
Neural Tube DefectsPro
Neuro · Spina bifida, AFP
PhakomatosesPro
Neuro · Neurocutaneous syndromes
Neurofibromatosis Type 1Pro
Neuro · Cafe-au-lait, Lisch
Neurofibromatosis Type 2Pro
Neuro · Bilateral schwannomas
Arnold-Chiari MalformationPro
Neuro · Type I vs II
Dandy-Walker MalformationPro
Neuro · Vermis agenesis
Tay-Sachs DiseasePro
Biochem · Cherry-red, no HSM
Fragile X Syndrome
Genetics · CGG repeats
NeuroblastomaPro
Peds · Dancing eyes, N-myc
TORCH Infections
Micro · Congenital CNS findings
CNS EmbryologyPro
Neuro · Neural tube vs neural crest
Niemann-Pick DiseasePro
Biochem · Sphingomyelinase, cherry-red macula
Lysosomal Storage Diseases
Biochem · Neurodegenerative enzyme defects (Krabbe, MLD)
+

To Be Added

Blueprint gaps

Topics the Neurology boards test that do not yet have a Bone Wizardry deep-dive. On the build list.

Cerebrovascular Disease and Stroke TIA and ABCD2 risk stratification, Carotid stenosis and carotid endarterectomy, Cerebral venous sinus thrombosis, Cervical and vertebral artery dissection, Aneurysmal SAH: nimodipine and vasospasm, Young and cryptogenic stroke workup (PFO, hypercoagulable), Watershed and border-zone infarction, Secondary prevention: antiplatelet, statin, BP control.
Headache and Facial Pain Trigeminal neuralgia (carbamazepine), Medication-overuse rebound headache, Post-traumatic and post-concussion headache, Low-CSF-pressure and post-LP headache, Occipital neuralgia, Hemicrania continua and paroxysmal hemicrania, Pediatric headache evaluation.
Seizures and Epilepsy Status epilepticus: benzodiazepine then fosphenytoin or levetiracetam, Absence seizures and ethosuximide, Juvenile myoclonic epilepsy, Simple versus complex febrile seizures, Antiepileptic drug selection and adverse effects, AED teratogenicity (valproate) and pregnancy planning, Temporal lobe epilepsy and mesial temporal sclerosis, Psychogenic nonepileptic seizures, Infantile spasms (West) and Lennox-Gastaut.
Neuromuscular and Demyelinating Disease Carpal tunnel and entrapment mononeuropathies (ulnar, radial, peroneal), Diabetic distal symmetric polyneuropathy, Charcot-Marie-Tooth disease, Inflammatory myopathies and statin myopathy, Muscular dystrophies (Duchenne, Becker, myotonic), Chronic inflammatory demyelinating polyneuropathy (CIDP), Optic neuritis and internuclear ophthalmoplegia, Neuromyelitis optica spectrum disorder (aquaporin-4), MS diagnosis: MRI, oligoclonal bands, McDonald criteria, EMG and nerve conduction study interpretation.
Movement Disorders Essential tremor (propranolol, primidone), Dystonias (cervical, blepharospasm, focal), Tardive dyskinesia, Tourette syndrome and tics, Atypical parkinsonism (PSP, MSA, corticobasal degeneration), Neuroleptic malignant syndrome and serotonin syndrome, Sydenham chorea, Functional movement disorders, Hemiballismus (contralateral subthalamic nucleus lesion).
Dementia and Delirium Creutzfeldt-Jakob disease (rapidly progressive, myoclonus), Mild cognitive impairment, Reversible dementia causes (B12, hypothyroidism, depression), Cholinesterase inhibitors and memantine, Cognitive screening (MMSE, MoCA), Pseudodementia (depression), Decision-making capacity and dementia safety, Delirium evaluation (CAM criteria, hyperactive vs hypoactive, precipitants and management).
CNS Infections Herpes simplex encephalitis (temporal lobe, acyclovir), Brain abscess, Neurocysticercosis, Lyme neuroborreliosis (facial palsy), Tuberculous meningitis, Rabies, Tetanus and neurotoxin-mediated disease, Meningococcal post-exposure prophylaxis.
Neuro-oncology, ICP and Hydrocephalus Primary CNS lymphoma, Vestibular schwannoma (acoustic neuroma), Increased intracranial pressure (Cushing triad, papilledema), Cerebral herniation syndromes (uncal, central, tonsillar), Hydrocephalus: communicating versus obstructive, Spinal epidural metastasis and cord compression, Paraneoplastic neurologic syndromes, Cerebral edema management (mannitol, hypertonic saline, steroids), Colloid cyst of the third ventricle.
Cranial Nerves, Vision and Vertigo Meniere disease, Visual field defects and localization (chiasm, optic tract, radiations), Third nerve palsy: compressive versus ischemic, Horner syndrome, Pupillary abnormalities (RAPD, Argyll Robertson, Adie tonic), Nystagmus patterns, Conductive versus sensorineural hearing loss, Cavernous sinus syndrome.
Spine, Radiculopathy and Neurotrauma Subacute combined degeneration (B12, dorsal columns and corticospinal), Syringomyelia, Concussion and return-to-play (post-concussion OMT), Traumatic brain injury severity and Glasgow Coma Scale, Diffuse axonal injury, Coma evaluation and brainstem reflexes, Brain death determination, Spinal shock versus neurogenic shock, Autonomic dysreflexia, Transverse myelitis (partial vs complete cord, MS and post-infectious causes).
Pediatric and Neurogenetic Disorders Cerebral palsy, Developmental delay and milestone assessment, Friedreich ataxia, Ataxia-telangiectasia, Spinal muscular atrophy (Werdnig-Hoffmann), Rett syndrome, Breath-holding spells.
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