Title: Big Ol' Bonewizardry Deck / Hex Clues / Neuro
Tags: hex-clues hex-clues::neuro

Q: What bug loves the temporal lobe?
A: HSV-1 encephalitis 🔥
temporal lobe necrosis 💀
acyclovir 💉 STAT

Q: What bug loves the hippocampus?
A: Rabies 🦠
Negri bodies + hydrophobia 🐕
retrograde axonal transport ☠️

Q: What bug loves the frontal lobe?
A: Congenital Rubella 🦠
cataracts + deafness + PDA 👶
blueberry muffin baby 🫐

Q: What bug loves the DCML tract?
A: T. pallidum (Tabes dorsalis) 🦠
loss of vibration + proprioception 🦶
3° syphilis
Argyll-Robertson 👁️

Q: What bug loves the parietal lobe?
A: Toxoplasma gondii 🦠
ring-enhancing lesions in AIDS 🎯
pyrimethamine + sulfadiazine 💊

Q: Where is serotonin synthesized?
A: Raphe nuclei 🧠
brainstem 🌈
5-HT source ☀️

Q: What is Cushing's triad?
A: ↑BP + ↓HR + irregular breathing 🧠
herniation imminent ☠️ 🚨

Q: What is an Encephalocele?
A: brain herniates through skull 🧠
usually occipital 🎈
NTD 🎀

Q: What is Arnold-Chiari?
A: cerebellar tonsils through foramen magnum 🧠
syringomyelia + hydrocephalus 💧 ⬇️

Q: Where is ACh synthesized?
A: Nucleus basalis of Meynert 🧠
↓ in Alzheimer's 🕯️
ACh source 💡

Q: What is Spina bifida aperta?
A: ↑AFP + AChE 🦴
open NTD, folate def 🌿 🕳️

Q: Where is NE synthesized?
A: Locus coeruleus 🧠
pons ⚡
NE source
panic center 🌪️

Q: What is a Schwannoma?
A: CN VIII, CP angle 🧠
unilateral hearing loss + tinnitus 👂
bilateral = NF2 🧬

Q: What is the autonomic nervous system?
A: involuntary control 🌪️
sympathetic + parasympathetic ⚖️ 🫁

Q: What is a Meningocele?
A: meninges only herniate 🦴
NO neural tissue 🫧
NTD 🎀

Q: What is the somatic nervous system?
A: voluntary skeletal control 💪
ACh at NMJ ⚡ 🎯

Q: What are the Watershed areas?
A: ACA/MCA + splenic flexure 🌊
vulnerable to hypoperfusion 💧 🧠

Q: What is Spina bifida occulta?
A: tuft of hair / dimple 🦴
vertebral arch fails fusion 🩹
no herniation 👶

Q: How does trigeminal neuralgia present?
A: electric shock face pain ⚡
CN V, light touch trigger 😬
carbamazepine 💊

Q: What is an Ependymoma?
A: 4th ventricle in kids 🧠
perivascular pseudorosettes 👶
hydrocephalus 💧

Q: What is an Astrocytoma?
A: #1 peds brain tumor 🧠
posterior fossa, Rosenthal fibers, GFAP+ 🧫 ⭐

Q: What is the sympathetic system?
A: fight-or-flight ⚡
T1-L2, NE/Epi 🌪️ 🏃

Q: What is the peripheral nervous system?
A: outside CNS 🧠
Schwann cells myelinate 🧀 🦶

Q: What is a Meningomyelocele?
A: Myelomeningocele 🦴
meninges + cord herniate 😱
neuro deficits, folate def 🌿

Q: What is the parasympathetic system?
A: rest-and-digest 🛌
CN III/VII/IX/X + S2-4, ACh 🍽️ 💤

Q: Where is dopamine synthesized?
A: Substantia Nigra + VTA 🧠
midbrain 💃
DA source
↓ in Parkinson's 🤲

Q: How does temporal arteritis present?
A: jaw claudication + vision loss 🔥
↑ESR 👁️
steroids NOW 💊

Q: What is an Oligodendroglioma?
A: fried-egg cells 🧠
chicken-wire capillaries + calcifications 🍳
frontal lobe 🐔

Q: What is the central nervous system?
A: CNS 🧠
brain + spinal cord 🦴
oligodendrocytes myelinate ⚡

Q: What are the 2 kinds of partial seizures?
A: simple (aware) vs complex (impaired) ⚡
one hemisphere 🎯 🧠

Q: What is a Hemangioblastoma?
A: cerebellar + von Hippel-Lindau 🧠
EPO → polycythemia 🔴 🩸

Q: What does the midbrain or mesencephalon give rise to?
A: CN III, IV + tectum + cerebral peduncles 🧠
mesencephalon ⚡ 🎯

Q: What is Anencephaly?
A: no forebrain 🧠
rostral NTD, ↑AFP ❌
folate def 🌿

Q: What happens to NE in anxiety and depression?
A: NE 🌪️
↑ in anxiety 🔄
↓ in depression
locus coeruleus 😰

Q: How does an epidural hematoma look on CT?
A: biconvex lens-shape 🩻
does NOT cross sutures 🚫 🍋

Q: How does an epidural hematoma present?
A: trauma → lucid interval → crash 🤕
middle meningeal artery ⏳
pterion fx 💀

Q: What is a Medulloblastoma?
A: cerebellum + morning vomit + ataxia 🧠
Homer-Wright rosettes 🤮
drop mets ⬇️

Q: What is a Dandy Walker malformation?
A: missing cerebellar vermis 🧠
cystic 4th ventricle → hydrocephalus 🎈 💧

Q: What is a Meningioma?
A: psammoma bodies + whorls 🧠
dura-based, estrogen-sensitive 🌀
benign 🥇

Q: What is Sturge-Weber?
A: port-wine stain (V1) + seizures 🍷
GNAQ mutation, sporadic 🔥
glaucoma 👁️

Q: How does a subdural hematoma present?
A: elderly/EtOH, slow onset 👴
bridging vein tear 🐌
days to weeks 🧠

Q: How do migraines present?
A: Migraine 🌈
unilateral throb + aura + photophobia 🤕
CGRP/5-HT pathway
triptans 💊

Q: What is a Pinealoma?
A: Parinaud (no upgaze) 🧠
obstructive hydrocephalus 👁️
precocious puberty (β-hCG) 👶

Q: How does a subarachnoid hemorrhage present?
A: thunderclap "worst HA of life" 💥
ruptured berry aneurysm 🤯
xanthochromia 🟡

Q: How does a subdural hematoma look on CT?
A: crescent-shape 🩻
CROSSES sutures 🌙
midline shift ⬅️

Q: What is Closed-angle glaucoma?
A: painful red eye + fixed mid-dilated pupil 👁️
canal of Schlemm blocked 🚨
emergency 🚑

Q: What is Glioblastoma multiforme?
A: butterfly across corpus callosum 🧠
pseudopalisading necrosis 🦋
worst prognosis ☠️

Q: What is a Craniopharyngioma?
A: "motor oil" cyst + calcs 🧠
Rathke's pouch remnant 🛢️
bitemporal hemianopia 👁️

Q: How do cluster headaches present?
A: periorbital + tearing + Horner 💥
men, EtOH trigger 👁️
O2 + sumatriptan 💨

Q: What does the hindbrain or rhombencephalon give rise to?
A: metencephalon → pons + cerebellum 🧠
myelencephalon → medulla 🎯 ⬇️

Q: What does the forebrain or prosencephalon give rise to?
A: telencephalon → cerebrum 🧠
diencephalon → thalamus + hypothalamus + retina 👁️ 🔝

Q: What are the most common places to metastasize to the brain?
A: Lung > Breast > Melanoma > Renal > Colon 🧠
gray-white junction 📍
mets > primaries 🎯

Q: How do tension headaches present?
A: bilateral band-like pressure 🎀
worse end-of-day 😣
no photo/nausea 😐

Q: What happens to serotonin in Parkinson's, anxiety, and depression?
A: 5-HT 🌈
↑ in Parkinson's 🔄
↓ in anxiety + depression
raphe nuclei ☀️

Q: What are the contents of the cavernous sinus?
A: CN III, IV, V1, V2, VI + ICA 🧠
+ postganglionic sympathetics 🎯 💨

Q: What happens to ACh in Parkinson's, Alzheimer's, and Huntington's?
A: ACh 🕯️
↑ in Parkinson's 🔄
↓ in Alzheimer's + Huntington's
nucleus basalis 💡

Q: What is Open-angle glaucoma?
A: painless peripheral vision loss 👁️
optic disc cupping 🐢
timolol, prostaglandins 💧

Q: What happens to dopamine in Huntington's, Parkinson's, and depression?
A: DA 💃
↑ in Huntington's 🔄
↓ in Parkinson's + depression
substantia nigra 🤲

Q: What is Tuberous Sclerosis?
A: ash-leaf spots + shagreen patches 🍃
cortical tubers, rhabdomyomas, angiomyolipomas 🥔
AD ⚡

Q: How does the parasympathetic system behave?
A: DUMBBELS 💩
Diarrhea, Urination, Miosis, Bradycardia, Bronchoconstriction, Emesis, Lacrimation, Salivation 💦
muscarinic toxicity 🍄