Title: Big Ol' Bonewizardry Deck / Hex Clues / Endo
Tags: hex-clues hex-clues::endo

Q: What is a Thyrotrope?
A: fires TSH 🎯
texts the thyroid gland 📲

Q: What is a Lactotroph?
A: secretes PRL 🎯
dopamine keeps it quiet 🎯
milk on demand 🤫

Q: What is a Corticotrope?
A: fires ACTH 🎯
stress response commander 🎯
talks to adrenal 🫡

Q: What is a Gonadotrope?
A: fires LH + FSH 🧬⚡
GnRH pulsatile required 🎯
sex hormone dispatcher 💊

Q: What does PTH do?
A: chews up bone → ↑Ca ↓PO4 🦴⚪
activates Vit D ⚡🔓
bone bank ATM 🏧

Q: What does GRH do?
A: stimulates GH from pituitary 📶

Q: What does TRH do?
A: stimulates TSH ⚡🔓
hypothalamus texting pituitary to text thyroid 📲

Q: What does Vit. D do?
A: Vitamin D 🎯
builds bone → ↑gut absorption Ca + PO4 🦴⚪
sunshine hormone 🌞

Q: What does CRH do?
A: stimulates ACTH ⚡🔓
stress signal from hypothalamus 📡🔬
panic button ⚠️

Q: What does PRL do?
A: Prolactin 🎯
milk production 🎯
inhibits GnRH → lactational amenorrhea 🔒🚫
natural birth control 🤱

Q: What does Dopamine do?
A: tonically inhibits PRL 🔒🚫
hypothalamus brake on prolactin 📡🔬
lose it = milk flood 🌊

Q: What does MSH do?
A: skin pigmentation 🤚🟡
co-released with ACTH 🎯
hyperpigmentation in Addison's 🟤

Q: What does GnRH do?
A: pulsatile LH + FSH release 🧬⚡
miss the pulse → gonadal silence 🎯
timing is everything ⏱️

Q: How does a SSoma present?
A: Somatostatinoma 🎯
constipation + steatorrhea + gallstones + diabetes 🎯
blocks everything 🚧

Q: What disease has Exophthalmos?
A: Graves Disease 🎯 exophthalmos + pretibial myxedema 🎯 TSH-receptor Ab 🛡️🎯 MCC hyperthyroid <50 👁️

Q: What disease has Enophthalmos?
A: Horner's Syndrome 🎯
ptosis
miosis
anhidrosis 🎯
sympathetic chain lesion 🎯
enophthalmos 🔗

Q: What does Erythropoietin do?
A: kidney → marrow 🫘💧
orders more RBCs 🩸🔴
altitude athletes abuse it 🏔️

Q: What is Gigantism?
A: ↑GH before epiphyseal closure 🎯
childhood acromegaly 🎯
plates still open → tall 📏

Q: What is Central DI?
A: posterior pituitary ↓ADH 🎯
dilute urine + hypernatremia 🎯
thirsty river 🌊

Q: Jod-Basedow
A: iodine-induced hyperthyroid 🎯
existing goiter + iodine load = runaway thyroid 🏃

Q: How does a VIPoma present?
A: VIPoma / WDHA 🎯
watery diarrhea + hypokalemia + achlorhydria 💩💧
VIP floods gut 🌊

Q: What do stomach chief cells secrete?
A: pepsinogen → pepsin in acid 🎯
stomach's enzyme factory 🏭

Q: What does TSH do?
A: releases T3 + T4 from thyroid 🎯
pituitary's text to thyroid 📲

Q: Wolff-Chaikoff
A: iodine → transient hypothyroid 🎯
blocks organification 🔒🚫
iodine paradox ⚠️

Q: What do parathyroid chief cells secrete?
A: secrete PTH 🎯
Ca cops of the body 🚔

Q: What is 2° hyperparathyroidism?
A: renal failure → ↓Vit D → ↓Ca → ↑PTH 🫘💧
kidney wrecks bones 💔

Q: What do T3 and T4 do?
A: growth + differentiation 🎯
↑BMR 🎯
the gas pedal hormones ⛽

Q: Iodine deficiency
A: MCC hypothyroid worldwide 🎯
Hashimoto's MCC in US 🗺️

Q: What does Endocrine mean?
A: secretion into blood 🎯
long-distance hormone delivery 📬

Q: Silent thyroiditis
A: post-partum painless hyperthyroid 🎯
resolves spontaneously 🎯
quiet thyroid fire 🔥

Q: What does Insulin do?
A: GLUT4 pushes glucose in 🎯
anabolic 🎯
↑glycogen + fat + protein 🎯
storage king 👑

Q: What is Plummer-Vinson syndrome?
A: esophageal webs + iron def anemia + dysphagia ⚙️🩸
↑SCC risk 🎗️

Q: What do TPO and Thymosin do?
A: T-cell maturation in thymus 📡🔬
graduating T-cells 🎓

Q: What do chromaffin cells produce?
A: epi + norepinephrine 🎯
adrenal medulla 🫘💧
adrenaline factory 🏭

Q: What does oxytocin do?
A: milk letdown + uterine contraction 🌸🤰
love + labor hormone 💕

Q: What is an Insulinoma?
A: beta-cell tumor 🎗️💀
↑insulin ↑C-peptide 🎯
Whipple's triad 🎯
hypoglycemia trap 🪤

Q: Cretinism
A: congenital hypothyroid 🎯
pot belly
protruding tongue
puffy face 🎯
developmental delay 🧠

Q: What does Hypothalamic Somatostatin do?
A: inhibits GH + TSH 🔒🚫
hypothalamus hitting the brakes 🛑

Q: What is 1° hyperparathyroidism?
A: parathyroid adenoma 🎯
stones
bones
groans 🦴⚪
↑Ca ↓PO4 ↑PTH 💎

Q: What is a Midget?
A: Laron Dwarfism 🎯
↓IGF-1 receptor sensitivity 🎯
↑GH (unusable) 🎯
receptor defect 🔇

Q: What does the Zona Reticularis make?
A: makes androgens / DHEA 💪♂️
sex zone 🎯
innermost layer 🔥

Q: What does the Zona Fasciculata make?
A: makes cortisol 🎯
sugar zone 🎯
stress hormone factory 🏭

Q: What is Cushing's disease?
A: pituitary ACTH adenoma 🎯
↑cortisol 🎯
suppresses w/ high-dose dex ⬆️📈
buffalo hump 🦬

Q: What does ACTH do?
A: cortisol from zona fasciculata 🎯
pituitary's order to adrenal 🫡

Q: What does CCK do?
A: gallbladder contracts
pancreatic enzymes 🎯
relaxes sphincter of Oddi 🎯
fat detector 🔍

Q: Lymphocytic
A: Lymphocytic Thyroiditis 🛡️🧬
postpartum 🎯
transient 🎯
painless 🎯
hyper → hypo 📉

Q: What does Aldosterone do?
A: reabsorbs Na
secretes H+/K+ 🎯
principal + intercalated cells 🎯
salt boss 🧂

Q: What does the Zona Glomerulosa make?
A: makes aldosterone 🎯
salt zone 🎯
outermost layer 🎯
RAAS controlled 🎚️

Q: What if both serum Ca and PO4 decrease?
A: Vit D Deficiency ⬇️❌
↓Ca ↓PO4 together 🎯
osteomalacia / rickets 🦴⚪
both low = D problem 🦴

Q: What does Testosterone do?
A: external male genitalia + virilization 🎯
DHT does the dirty work in skin/prostate 🛠️

Q: What does Epinephrine do?
A: gluconeogenesis + glycogenolysis 🎯
fight-or-flight fuel 🎯
adrenal medulla's big gun 🔫

Q: What does Gastrin do?
A: G cells → parietal cells 🎯
stimulates IF + HCl ⚡🔓
from antrum 🧪

Q: What is Diabetes Insipidus?
A: ↓ADH (central) or unresponsive kidney (nephrogenic) 🫘💧
polyuria + dilute urine 🌊

Q: What is Familial Hypocalciuric Hypercalcemia?
A: Ca-sensing receptor defect 🎯
↓urinary Ca 🎯
mild ↑serum Ca 😌

Q: What is the Dawn phenomenon?
A: nocturnal GH surge → morning hyperglycemia 🎯
no preceding hypoglycemia 🎯
vs Somogyi 🌙

Q: What is Erythrasma?
A: Corynebacterium minutissimum 🎯
coral-red Wood's lamp glow 🎯
skin fold rash 🌺

Q: What is Hungry Bone syndrome?
A: post-parathyroidectomy 🎯
bone sucks in Ca aggressively 🦴⚪
severe hypocalcemia ⬇️

Q: What is MEN II?
A: MEN 2A / Sipple's 🎯
Pheo + Medullary thyroid CA + Parathyroid hyperplasia 🎯
RET mutation 🔬

Q: What does Calcitonin do?
A: inhibits osteoclasts → ↓serum Ca 🔒🚫
from thyroid C cells 🎯
bone's chill pill 💊

Q: What receptors do protein hormones use?
A: membrane receptors 🎯
2nd messengers (cAMP, IP3) 🎯
can't cross membrane 🚧

Q: What is Autocrine?
A: hormone acts on itself 🎯
e.g., thymosin/thymopoietin 🎯
talking to yourself 🗣️

Q: What is Nelson's syndrome?
A: post-bilateral adrenalectomy 🫘💧
pituitary tumor grows unchecked 🎗️💀
↑ACTH → hyperpigmentation 🟤

Q: What receptors do steroid hormones use?
A: intracellular/nuclear receptors 🎯
direct DNA binding 🧬🔬
cross membrane freely 🚶

Q: What is Holocrine?
A: whole cell secreted 🎯
e.g., sebaceous glands 📡🔬
sacrifice yourself 🫡

Q: What is Apocrine?
A: apex of cell secreted 🎯
axillary sweat + mammary 🎗️🌸
partial self-sacrifice ✂️

Q: What does duodenal Somatostatin do?
A: inhibits secretin
motilin
CCK
gastrin 🔒🚫
GI's all-purpose brake 🛑

Q: What is Waterhouse Friderichsen?
A: bilateral adrenal hemorrhage 🩸💧
N. meningitidis sepsis 🎯
acute adrenal crisis 🚨

Q: Euthyroid sick syndrome
A: ↓T3 ↑rT3 normal TSH 🎯
critical illness shuts off conversion 🎯
sick thyroid trick 🎭

Q: What does ADH do?
A: V2 → aquaporins in CCD → concentrated urine 🎯
V1 vasoconstricts 🎯
water conservator 🏺

Q: What is the most common cause of 1° hypoparathyroidism?
A: Iatrogenic Hypoparathyroidism 🎯
MCC = post-thyroidectomy 🎯
parathyroids accidentally removed 🎯
surgical oops 😬

Q: Riedel's struma
A: IgG4-related fibrosing thyroiditis 🎯
rock-hard 'woody' neck 🎯
hypothyroid 🔒

Q: What is SIADH?
A: excess ADH → euvolemic hyponatremia ⬆️💥
concentrated urine
↓serum osm 🎯
diluted blood 🌊

Q: What does GIP do?
A: incretin effect → ↑postprandial insulin 🎯
glucose-triggered insulin booster 🚀

Q: What does Müllerian Inhibiting Factor do?
A: regresses Müllerian ducts in males 🎯
Sertoli cells 🎯
makes room for Wolffian 🏗️

Q: What is Pseudohypoparathyroidism?
A: G-protein defect → end-organ PTH resistance 🎯
↓Ca ↑PO4 ↑PTH 🎯
Albright osteodystrophy 🦴

Q: What is Conn's syndrome?
A: adrenal adenoma → ↑aldosterone 🫘💧
HTN + ↓K + ↓renin 🎯
salt villain 🦹

Q: What is Pseudopseudohypoparathyroidism?
A: Albright phenotype + normal Ca/PTH 🎯
paternal imprinting 🎭

Q: What is Factitious Hypoglycemia?
A: exogenous insulin 📡🔬
↑insulin ↓C-peptide 🎯
vs insulinoma: C-peptide tells truth 🔍

Q: What is the primary regulatory control for the Zona Reticularis?
A: ACTH/CRH 🎯
same as fasciculata 🎯
pituitary's androgen dial 🎚️

Q: What is the primary regulatory Control for the Zona Fasciculata?
A: ACTH/CRH 🎯
pituitary's cortisol switch ⚡

Q: De Quervain's
A: De Quervain's Thyroiditis 🎯
post-viral
painful tender thyroid 🦠🧬
granulomatous self-limited 📡🔬
ESR ↑ 🔥

Q: What is MEN III?
A: MEN 2B 🎯
Pheo + Medullary thyroid CA + mucosal neuromas + marfanoid habitus 📡🔬
RET mutation 🔬

Q: What is the Somogyi Effect?
A: nocturnal hypoglycemia → counter-regulatory rebound 🎯
morning hyperglycemia 2° to low overnight ⬇️📉
vs Dawn 🌅

Q: What does Glucagon do?
A: gluconeogenesis + glycogenolysis + lipolysis + ketogenesis 🎯
insulin's nemesis 🆚

Q: What does Exocrine mean?
A: secretion via ducts into non-blood/cavity 🎯
e.g., pancreatic enzymes 🎯
piped delivery 🪣

Q: What is Plummer's syndrome?
A: toxic multinodular goiter 🎯
MCC hyperthyroid after age 50 🎯
many nodules on fire 🔥

Q: What is Psychogenic Polydipsia?
A: compulsive water drinking → ↓plasma osm 🎯
dilute urine 🎯
corrects w/ restriction 🚱

Q: What is the primary regulatory control for the Zona Glomerulosa?
A: RAAS primary controller 🎯
renin → angiotensin → aldosterone 🔗

Q: What is Nephrogenic DI?
A: ADH receptor unresponsive 🎯
lithium
demeclocycline
hypercalcemia 🎯
kidney ignores ADH 🙉

Q: How does DKA present?
A: Type 1 DM 🎯
Kussmaul respirations + fruity breath 🎯
anion-gap acidosis 🎯
AMS 🧠

Q: What is Paracrine?
A: hormone acts on neighboring cell 🎯
e.g., GI somatostatin 🎯
whispers to neighbor 🗣️

Q: What is Type II DM?
A: Type 2 DM 🎯
insulin resistance 🎯
acanthosis nigricans 🎯
HHNK coma risk 🎯
fasting glucose ≥126 📊

Q: What does LH do?
A: Leydig → testosterone 💪♂️
ovary → ovulation surge + progesterone 🥚🌸
the trigger hormone ⚡

Q: What is MEN I?
A: MEN I / Wermer's 🎯
Pancreatic + Pituitary + Parathyroid adenomas 🎯
MEN1 gene 🧬🔬
'3 Ps' 🅿️

Q: What does FSH do?
A: Sertoli → sperm + inhibin 🎯
granulosa → estrogen via aromatase 🌸♀️
fertility's silent worker 🧫

Q: What is the difference b/w DI and SIADH?
A: DI vs SIADH 🎯
DI = dilute urine + hypernatremia 🎯
SIADH = concentrated urine + hyponatremia 🎯
opposites ⚖️

Q: What does Secretin do?
A: pancreatic HCO3 → neutralizes acid 🎯
inhibits gastrin + tightens pylorus 🔒🚫
from S cells 🧫

Q: What is Addison's disease?
A: autoimmune adrenal destruction 🛡️💥
hyperpigmentation + ↑ACTH 🎯
hypoNa + hyperK 🧂

Q: What is the primary regulatory control for the chromaffin cells?
A: preganglionic sympathetic fibers 🎯
splanchnic nerve 🎯
direct neural input ⚡

Q: What does the Water Deprivation test tell you?
A: DI fails to concentrate urine 🎯
vs psychogenic polydipsia 🎯
body's thirst exam 📝

Q: What is Cushing's syndrome?
A: hypercortisolism 🎯
pituitary
adrenal tumor
ectopic ACTH
iatrogenic 🎗️💀
buffalo hump 🦬

Q: If the low-dose dexamethasone test suppresses, what does that tell you?
A: Low-dose Dex Suppresses ⬇️📉
normal HPA axis 🎯
rules out Cushing's 🎯
also suppresses obese/depressed 😴

Q: Grave's
A: Graves' Disease 🎯
MCC hyperthyroid
TSI antibody 🛡️🎯
exophthalmos + pretibial myxedema 🎯
symmetric goiter 🦋

Q: If the low-dose dexamethasone test does not suppress, what does that tell you?
A: Cushing's Confirmed 🎯
low-dose dex fails to suppress ⬇️📉
proceed to high-dose dex to localize 🔍

Q: What is Syndrome X = Metabolic Syndrome?
A: HTN + dyslipidemia + hyperinsulinemia + central obesity + acanthosis nigricans 🎯
pre-DM 🩸

Q: What is Type I DM?
A: Type 1 DM 🎯
autoimmune β-cell destruction 🛡️💥
anti-islet/GAD Ab 🛡️🎯
Coxsackie B trigger 🎯
DKA prone 🚨

Q: What organs do not require insulin?
A: BRICKLE Organs 🎯
no insulin needed 🎯
Brain
RBC
Intestine
Cornea
Kidney
Liver
Exercising muscle 🔓

Q: What is Merocrine?
A: exocytosis
no cell loss 🎯
e.g., eccrine sweat + pancreas 🎯
cleanest secretion ✨

Q: If the high-dose dexamethasone test suppresses, what does that tell you?
A: Pituitary Cushing's 🎯
high-dose dex suppresses ⬆️📈
ACTH adenoma confirmed 🎯
refer to neurosurgery 🧠

Q: What does Motilin do?
A: stimulates MMC between meals ⚡🔓
erythromycin is a motilin agonist ⚡🔓
housekeeping wave 🧹

Q: What is a Pheochromocytoma?
A: adrenal catecholamine tumor 🎗️💀
5 Ps: episodic HTN
palpitations
diaphoresis
headache
pallor 🤕🧠
↑urine metanephrines 🧪

Q: What does ANP do?
A: atrial stretch → ↓aldosterone 🎯
dilates afferent arteriole → natriuresis 🎯
heart's pressure relief valve 🔓

Q: What are the steroid hormones?
A: PET CAD 🎯
Progesterone
Estrogen
Testosterone
Cortisol
Aldosterone
Vit D 🌸♀️
thyroid acts steroid-like 🦋