Title: Big Ol' Bonewizardry Deck / Hex Clues / MSK
Tags: hex-clues hex-clues::msk

Q: Where is CK-BB found?
A: CNS injury/stroke 🧠⚡
brain leaks enzymes 💧

Q: Where is CK-MB found?
A: rises 4-6h post-MI ❤️
peaks 24h 🔥
gold for reinfarction 📈

Q: Where is CK-MM found?
A: rhabdo 💪
myositis 🏋️
muscular dystrophy - muscles crying CK 😤

Q: What is Myositis?
A: single muscle inflammation 🔥
focal pain 🤕
local fire 🔥

Q: What is Osteopenia?
A: DEXA T-score −1.0 to −2.5 🦴
pre-osteoporosis 📉
↓bone mass 📏

Q: What is Osteomyelitis?
A: S. aureus MCC 🦴
Salmonella sickle cell 🦠
bone-eating bacteria 🦠

Q: What is Still's' Disease?
A: daily spiking fevers 🌡️
salmon rash 🐟
juvenile RA 🔥

Q: What is a light chain composed of?
A: Actin 🪡
thin filament 💪
light chain of sarcomere 🪡

Q: What is a heavy chain composed of?
A: Myosin 🏋️
thick filament 💪
heavy chain of sarcomere 🥩

Q: What is Scleroderma?
A: anti-Scl-70 diffuse 🧊
anti-centromere CREST 🔒
fibrosis 🧊

Q: What are Tophi?
A: urate crystals + giant cells 🧲🦴
gout's chalky deposits 🧂

Q: What is Podagra?
A: urate crystals 🦶
big toe on fire 🔥
classic gout attack 🧲

Q: What is Rheumatoid Factor?
A: IgM vs IgG Fc 🔬💉
antibody fighting its own antibody 🤦

Q: What is Osteosclerosis?
A: scarring thickens bone 🦴🪨
dense marble bone 🪨

Q: What is Becker's MD?
A: dystrophin missense 💪
sx after age 5 😐
milder Duchenne 🧬

Q: What Ab is associated with CREST?
A: Anti-centromere Ab 🔬
marker for CREST syndrome 🎯
limited scleroderma 🧊

Q: What is Atonic cerebral palsy?
A: no muscle tone 😶
floppy infant 💪
like a ragdoll 🪆

Q: What is Felty's syndrome?
A: RA + ↓leukopenia + splenomegaly 🩸💀
RA's worst trio 🩸

Q: What is Lumbar Stenosis?
A: MRI 'hourglass' ⏳
low back pain 🦴
cord squeezed ⏳

Q: What band of the sarcomere does not change length?
A: thick myosin filaments 📏💪
length UNCHANGED during contraction 📏

Q: What is Fibromyalgia?
A: 11+ trigger points 🤕
hurt everywhere all the time 😫
no structural cause 🕳️

Q: What is Gout?
A: urate crystals
(-) birefringent 🧲🦶
big toe attacks 🔬

Q: What is Pseudogout?
A: pyrophosphate crystals 🧊
knees/wrists 🦵
(+) birefringent
gout's impersonator 🎭

Q: What is Behçet's syndrome?
A: oral + genital ulcers 👄
uveitis 🔥
triple-threat silk road disease 🌍

Q: What is Disk Herniation?
A: straight leg raise → shooting pain 🤕🦵
nucleus pulposus pops out 💥

Q: Which vasculitis has a high platelet count?
A: Kawasaki Disease 🩸
↑platelets 🌡️
strawberry tongue
peeling palms
kids only 👶

Q: What is Goodpasture's?
A: anti-GBM Ab 🫁
attacks lung + kidney 🩸
RPGN + hemoptysis 💧

Q: What is Septic arthritis?
A: Staph aureus MCC 🔥
fever + hot joint 🦠
drain + abx 💉

Q: What is Osteoarthritis?
A: pain worse w/ activity 🏃
PIP/DIP joints 🦴
Heberden's nodes 🦴

Q: What is Sjögren's syndrome?
A: dry eyes + dry mouth 💧
anti-Ro/La 😢
females + RA 🌸

Q: What is Churg-Strauss?
A: Churg-Strauss / EGPA 🫁
asthma + ↑eosinophils 🔥
multi-organ vasculitis
p-ANCA 🩸

Q: What is Legg-Calves-Perthes?
A: femoral head AVN 🏃
childhood limp 🦴
blood cut off ✂️

Q: What is Polyarteritis Nodosa?
A: p-ANCA 🩸
medium vessels 🫀
gut + kidney
Hep B 🦠

Q: What is Osteogenesis Imperfecta?
A: blue sclera 🦴
brittle bones 💙
type I collagen defect 🧬

Q: What is Rheumatoid Arthritis?
A: stiff in the morning 🌅
MCP/PIP joints 💪
ulnar deviation 🔥

Q: What platelet count do most types of vasculitis have?
A: Low Platelets in Vasculitis 🩸
consumed in vessel-wall inflammation 📉
except Kawasaki ↑ 📊

Q: How does a myopathic muscle disease present?
A: Myopathic Pattern 💪
proximal weakness + pain 🤕
trouble getting up from chair
no fasciculations 💺

Q: What is Reiter's syndrome?
A: Reiter's / Reactive Arthritis 👁️
can't see
can't pee
can't climb a tree 💧
post-infection 🌳

Q: Which vasculitis has a normal platelet count?
A: Henoch-Schönlein Purpura 🩸
normal platelets 📊
IgA vasculitis
palpable purpura 🍇

Q: What is Werdnig-Hoffman?
A: Werdnig-Hoffmann 👶
fasciculations in newborn 😶
no anterior horn cells
floppy + fasciculating 🧬

Q: What is Takayasu's Arteritis?
A: pulseless disease 📡
Asian women 💔
aorta inflammation 🔥

Q: What is Wegener's Granulomatosis?
A: GPA / Wegener's 👃
c-ANCA 🫁
ENT + lung + kidney
granulomatous vasculitis 💥

Q: What is Polymyositis?
A: anti-Jo-1 💪
proximal weakness + pain 🔥
no rash 🤕

Q: What is Osgood-Schlatter?
A: tibial tubercle AVN 🦵
teen knee pain growth spurts 🤕
'ouch knob' 📍

Q: What is Dermatomyositis?
A: heliotrope rash 💅
Gottron's papules 🔥
rule out malignancy 🎗️

Q: Where does bone cancer metastasis occur from?
A: Bone Mets Source 🦴
Breast
Prostate
Lung
Kidney 🎗️
mnemonic: BPro-LuKi 🦴

Q: How does a neurogenic muscle disease present?
A: Neurogenic Pattern ⚡
distal weakness + fasciculations 💪
LMN signs
no strength at fingertips 🤙

Q: What is Osteitis Fibrosis cystica?
A: Osteitis Fibrosa Cystica 🦴
high PTH 🕳️
bone holes
brown tumors
PTH eating bone 🍴

Q: What is Osteonecrosis = Legg- Calve- Perthes?
A: Osteonecrosis / LCP 🦴
wedge-shaped femoral head necrosis 🔺
blood cut off → bone dies ✂️

Q: What is Cauda Equina Syndrome?
A: saddle anesthesia 🐴
can't feel butt/thighs 😶
emergent MRI + surgery 🚨

Q: What is Osteoporosis?
A: ↓bone matrix 🦴
compression fractures 📉
not calcification loss 🦴

Q: What is Diabetic Neuropathy?
A: glove + stocking 🧤
sorbitol deposition 🧦
sugar crystallizing nerves 🍬

Q: What is Polymyalgia Rheumatica?
A: weak + painful shoulders + hips 🔥
temporal arteritis link 💪
ESR↑ 📈

Q: What is Osteopetrosis?
A: ↓osteoclast activity 🦴
marble bones 🪨
obliterates own marrow
ironic 🤪

Q: What is Slipped Capital Femoral Epiphysis?
A: SCFE 🍔
obese teenage boys 🦵
dull achy hip + limp
femoral head slips off physis 🫨

Q: What is Costochondritis?
A: chest wall tenderness 🫁
worse with deep breath 🤕
rib-cartilage joint inflamed 🔥

Q: What is Ochronosis = Alkaptonuria?
A: black urine 🖤
childhood OA 🍵
homogentisic acid oxidase def 🧬

Q: Smooth muscle contraction
A: intracellular Ca contracts 🧬
needs extracellular Ca for 2nd messenger 💉
indirect trigger 📡

Q: What is CREST syndrome?
A: Calcinosis
Raynaud's
Esophageal dysmotility
Sclerodactyly
Telangiectasia 🧊🫀
limited scleroderma 🖐️

Q: What is Duchenne MD?
A: dystrophin frameshift 💪
Gower sign 🧬
calf pseudohypertrophy
X-linked 👦

Q: Cardiac muscle contraction
A: Ca-induced Ca release ❤️
extracellular Ca triggers intracellular store ⚡
cascade fire 🔥

Q: What is Ataxia Telangiectasia?
A: spider veins + IgA def 🕷️
DNA breakage repair defect 🧬
mucosal infections 🦠

Q: What is Metachromatic Leukodystrophy?
A: arylsulfatase A def 🧠
demyelination 🔬
kid with adult MS 👦

Q: What is Polio?
A: asymmetric fasciculations in child ⚡
2 wk post-gastroenteritis 🦠
virus hides in DRG 🫥

Q: What is Friedreich's ataxia?
A: scoliosis + retinitis pigmentosa 🚶
hypertrophic CMP 🎵
trinucleotide repeat 🧬

Q: What is ALS?
A: middle-aged male ⬇️
fasciculations + descending paralysis 🔥
all motor neurons
no sensory 🤐

Q: Skeletal muscle contraction
A: intracellular Ca only 🔌
100% electro-chemically coupled 💪
no autonomics 🚫

Q: What is Guillain-Barre?
A: ascending paralysis ⬆️
2 wk post-Campylobacter 🦠
autoimmune peripheral nerve attack 🔬

Q: What is Myotonic Dystrophy?
A: can't let go of handshake 🤝
bird's beak face 😬
trinucleotide repeat 🧬

Q: What is Myasthenia gravis?
A: gets weaker as day goes 😪
anti-AChR Ab 💉
edrophonium improves
rule out thymoma 🫀

Q: What is Choreoathetosis?
A: dance-like movements 💃
hand-wringing 🧠
basal ganglia damage permanent 🕺

Q: What is Ankylosing Spondylitis?
A: bamboo spine 🏛️
stiff in morning 🦴
HLA-B27
ligament ossification → kyphosis 🔒

Q: What is Myasthenic syndrome = Lambert-Eaton?
A: gets STRONGER as day goes ⬆️
repetitive EMG improves it 🔋
small cell CA association 🎗️

Q: What is Multiple sclerosis?
A: anti-myelin Ab 🧠
young woman ⚡
vision problems come and go
trigeminal neuralgia 👁️