Title: Big Ol' Bonewizardry Deck / Hex Clues / Immuno
Tags: hex-clues hex-clues::immuno

Q: What do Th1 cells secrete?
A: IFN-γ + IL-2 🎯
arms macrophages 🛡️🍽️
Th1 killswitch 🎯
cell-mediated 🎯

Q: What is Mixed CT disease?
A: Anti-RNP Ab 🛡️🎯
SLE + scleroderma + polymyositis 🤚🟡
overlap stew 🍲

Q: What is CREST syndrome?
A: Anti-centromere Ab 🛡️🎯
CREST 🎯
limited scleroderma 🤚🟡
Raynaud's first ❄️

Q: Which cytokine do macrophages produce?
A: IL-1 🎯
endogenous pyrogen 📡🔬
acute inflammation 🚨

Q: What is Berger's?
A: IgA Nephropathy 🛡️🎯
hematuria 2 wks post-URI 🎯
mesangial IgA 🩸

Q: What type of immunity does TH2 provide?
A: Humoral / B-cell 🎯
anti-parasite + allergy 🪱🦠
IL-4/5/10/13 🤧

Q: What does IL-5 do?
A: IgA class switch + eosinophils 🛡️🌸
"5 Alive" 🟢

Q: What is Vitiligo?
A: Anti-melanocyte Ab 🛡️🎯
vitiligo 🎯
white patches, autoimmune 🤍

Q: What does the viral load tell you?
A: HIV RNA copies 🎯
tracks progression + tx response 🎯
goal: undetectable 🎯

Q: What type of immunity does TH1 provide?
A: Cell-mediated 🎯
CD8 + macrophage 🛡️🍽️
intracellular pathogens ⚡

Q: What is Ataxia Telangiectasia?
A: ↓IgA + cerebellar ataxia 🛡️🎯
ATM gene, DNA repair 🧬

Q: What is Dermatomyositis?
A: Anti-Jo-1 Ab 🛡️🎯
heliotrope rash + Gottron papules 🔴💢
myositis 💜

Q: What is Hyper IgM syndrome?
A: ↑IgM, ↓all others 🛡️🎯
CD40L defect, no class switch 🚫

Q: What is Warm hemolysis?
A: Warm AIHA 🎯
IgG anti-Rh 🛡️🎯
hemolysis at body temp 🎯
SLE/CLL 🔥

Q: What is Type II Autoimmune Hepatitis?
A: Anti-LKM Ab 🛡️🎯
kids, type 2 AIH 🎯
liver/kidney microsomes 🧒

Q: What is Wegener's?
A: c-ANCA / GPA 🎯
ENT + lung + kidney 🫁💨
saddle nose, hemoptysis 🩸

Q: What do Th2 cells secrete?
A: IL-4, 5, 6, 10, 13 🎯
B-cell help + IgE 🛡️🎯
humoral, allergy 🌸

Q: What is Hashimoto's?
A: Anti-TPO / anti-microsomal 🎯
hypothyroid, goiter 🎯
Hürthle cells 🎯
HLA-DR5 🧊

Q: What diseases are associated with HLA- A3?
A: Hemochromatosis 🎯
iron overload, HFE gene 🟫

Q: What is SLE cerebritis?
A: Anti-neuronal / anti-ribosomal P 🧠⚡
SLE cerebritis 🧠⚡
psychosis/seizures in lupus ⚡

Q: What is Type I Autoimmune Hepatitis?
A: Anti-SM / ASMA 🎯
young women, type 1 AIH 🎯
+ANA 🍷

Q: What is Job's Syndrome?
A: Job Syndrome (Hyper-IgE) 🛡️🎯
FATED - Face, Abscesses (cold), Teeth, IgE, Derm 🛡️🎯
STAT3 defect 🧬

Q: What is Bullous pemphigoid?
A: Anti-hemidesmosome (BP180) 🎯
tense bullae, elderly 🎯
Nikolsky NEG 👵

Q: What is Mononucleosis?
A: Heterophile Ab (Monospot) 🛡️🎯
EBV, sore throat + splenomegaly 🎯
kissing disease 💏

Q: What is Scleroderma?
A: Anti-Scl-70 (anti-TopoI) 🎯
diffuse fibrosis, tight skin 🤚🟡
collagen overdrive 🧱

Q: What do B cell deficiency patients die of?
A: Encapsulated bacteria 🎯
SHiNE SKiS 🎯
no opsonization 🎯
Strep pneumo, H flu, Neisseria 💀

Q: What diseases are associated with HLA- DQ2/DQ8?
A: Celiac Disease 🎯
gluten = enemy 🥖

Q: What is Drug-induced Lupus?
A: Anti-histone Ab 🛡️🎯
HIPPPE drugs 🎯
Hydralazine, INH, Procainamide, Phenytoin, Penicillamine, Etanercept 🎯
drug-induced lupus 🦋

Q: What does the CD4 count tell you?
A: HIV status 📡🔬
normal ≈1,000 🎯
☠️

Q: Which of your cells express MHC-1?
A: MHC-I 🎯
ALL nucleated cells 🎯
except RBCs + platelets 🔴

Q: What does IL-8 do?
A: neutrophil chemotaxis 🛡️⚪
"clean up on aisle 8" 🚒

Q: What is MPGN Type II?
A: C3 Nephritic Factor 🎯
MPGN Type II 🎯
Ab vs C3 convertase → persistent activation 🧬

Q: Which cytokines do TH cells stimulate?
A: Everything except IL-1 🎯
Th conducts orchestra 🎯
IL-1 = macrophage solo 🎼

Q: What is Post-Strep GN?
A: ASO Ab 🛡️🎯
nephritic, 2 wks post-strep 🦠⛓️
lumpy-bumpy IgG/C3 deposits 🩸

Q: What is Heavy Chain Disease?
A: IgA myeloma of GI 🛡️🎯
malabsorption + lymphoma 🍞

Q: What is Hairy Cell Leukemia?
A: fried egg + TRAP+ 🎯
splenomegaly, dry tap 🎯
cladribine 💉

Q: What diseases are associated with HLA- DR3?
A: 🧬3️⃣ HLA-DR3 🎯
DM1
SLE
Graves 🎯
autoimmune trio 🔫

Q: What does IL-2 do?
A: recruits everyone (T-cell growth) 🎯
Daclizumab blocks it 🛑

Q: What is Selective IgG2 Deficiency?
A: recurrent encapsulated infections 🦠🌡️
can't fight polysaccharide caps 🧫

Q: What is DiGeorge Syndrome?
A: DiGeorge (22q11) 🎯
CATCH-22 🎯
no thymus + no parathyroids 📡🔬
tetany + tetralogy 🫀

Q: What diseases are associated with HLA- DR4?
A: 🧬4️⃣ HLA-DR4 🎯
RA
DM1 🎯
"4 walls of a rheum" 🦴

Q: What is Alport's?
A: Alport syndrome 🎯
can't see, hear, or pee 🎯
type IV collagen defect 🧬

Q: What do T cell deficiency patients die of?
A: Viruses + fungi 🍄🦠
CMV, EBV, PCP, Candida 🍄🦠
no cell-mediated ☠️

Q: What does IL-3 do?
A: bone marrow stem cell growth 🦴⚪
like GM-CSF 🩸

Q: What is 1° Biliary Cirrhosis?
A: Anti-mitochondrial Ab 🛡️🎯
PBC - pruritic women 🎯
granulomatous bile duct destruction 🪶

Q: Who are the CD4 cells?
A: T helper (CD4) 🎯
recognizes MHC-II 🎯
APC presents non-self 🎭

Q: What is Sjögrens?
A: Anti-SSA / anti-Ro 🎯
dry eyes + dry mouth + arthritis 🎯
↑lymphoma risk 👁️

Q: What diseases are associated with HLA- DR5?
A: 🧬5️⃣ HLA-DR5 🎯
Pernicious Anemia
Hashimoto's 📡🔬
5 = B12 + Thyroid 🧊

Q: What is Pernicious anemia?
A: Anti-IF / Anti-parietal Ab 🛡️🎯
B12 def → megaloblastic 🎯
+ neuro sx (SCD) 🦶

Q: What is Celiac sprue?
A: Anti-tTG / anti-gliadin / anti-endomysial 🎯
steatorrhea + dermatitis herpetiformis 🤚🟡
HLA-DQ2/DQ8 🥖

Q: What does IL-10 do?
A: chills out Th1, boosts Th2 🎯
anti-inflammatory (like TGF-β) 🧊

Q: What does IL-12 do?
A: activates Th1, kills Th2 ⚡🔓
NK cell + cell-mediated ⚡

Q: What is Gastritis Type A?
A: Anti-parietal cell Ab 🛡️🎯
type A atrophic gastritis 🎯
fundus/body 📡🔬
adenoCA risk 🎯

Q: What is Wiskott-Aldrich?
A: Wiskott-Aldrich (WATER) 🎯
WAS: eczema + thrombocytopenia + recurrent infx 🩸🟣
X-linked, WASP gene 🧬

Q: What does IL-6 do?
A: acute phase reactants 🎯
↑CRP, ESR, fibrinogen 🌡️

Q: What is Guillain-Barre?
A: Anti-ganglioside Ab 🛡️🎯
ascending paralysis post-URI 🎯
molecular mimicry (Campy) 🎯
IVIG/plasma 💉

Q: What is Multiple sclerosis?
A: Anti-myelin Ab 🛡️🎯
young woman, optic neuritis 🎯
oligoclonal bands, MRI plaques 📷🔬
HLA-DR2 🧠

Q: What is Grave's disease?
A: Anti-TSHr Ab 🛡️🎯
exophthalmos + pretibial myxedema 🎯
hyperthyroid 🎯
HLA-DR3 🔥

Q: What is DM type 1?
A: Anti-islet / Anti-GAD-65 Ab 🛡️🎯
polyuria + polydipsia + wt loss 🎯
β-cell destruction 🎯
HLA-DR3/4 💉

Q: Who are the CD8 cells?
A: Cytotoxic T (CD8) 🎯
recognizes MHC-I (self) 🎯
kills infected/tumor cells 💀

Q: What is Selective IgA Deficiency?
A: transfusion anaphylaxis 🩸💉
mucosal infections 🦠🌡️
MC primary immunodef 🌊

Q: What is Goodpasture's?
A: Anti-GBM Ab 🛡️🎯
lung + kidney 🫁💨
RPGN with crescents 🎯
linear IF 🎯
HLA-DR2 🩸

Q: What organs have the most CD4 receptors?
A: CD4 hotspots 🎯
blood vessels, brain, testes, cervix, rectum 🧠⚡
HIV target zones 🎯

Q: What is 1° Sclerosing Cholangitis?
A: p-ANCA / PSC 🎯
onion-skin bile ducts 🤚🟡
strongly tied to UC 🧊

Q: What is Pemphigus vulgaris?
A: Anti-desmoglein Ab 🛡️🎯
flaccid bullae + oral ulcers 🎯
Nikolsky POS 🎯
tombstones on IF 🪦

Q: What is Bruton's Agammaglobulinemia?
A: Bruton XLA 🎯
boys, no B cells, no Ab 🛡️🧬
BTK defect 🎯
encapsulated infx 🦠

Q: What is SCID?
A: bubble baby, dies by 18 mo 🎯
ADA def or X-linked γ-chain 🎯
BMT 💀

Q: What is Dermatitis herpetiformis?
A: Anti-endomysial / anti-tTG 🎯
itchy vesicles on knees/elbows 🎯
celiac skin twin 🤚🟡
dapsone 💊

Q: What is Multiple Myeloma?
A: CRAB 🎯
IgG monoclonal, rouleaux, M spike 🛡️🎯
Bence-Jones 🦀

Q: What diseases are associated with HLA- DR2?
A: 🧬2️⃣ HLA-DR2 🎯
MS
Hay Fever
SLE
Goodpasture 🌡️🔥
"DR2 makes you sneeze and pee blood" 🫁

Q: What is Chronic Mucocutaneous Candidiasis?
A: T-cell defect vs Candida 🍄🦠
AIRE / STAT1 mutations 🦠

Q: What is SLE?
A: Anti-dsDNA, anti-Sm, anti-cardiolipin 🧬🔬
malar rash, photosensitivity 🔴💢
renal = MCC death ☠️

Q: What is Common Variable Hypogammaglobulinemia?
A: CVID 🎯
B cells fail to differentiate 🛡️🧬
low Ab, autoimmune + lymphoma risk 🦠

Q: What is Myasthenia gravis?
A: Anti-AChR Ab 🛡️🎯
ptosis, weaker through day 🎯
edrophonium STRONGER 🎯
rule out thymoma 🎯

Q: What diseases are associated with HLA- B27?
A: PAIR 🎯
Psoriatic, Ankylosing Spondylitis, IBD, Reactive Arthritis 🎯
seronegative spondyloarthropathies 🎯

Q: What is Paroxysmal hemolysis?
A: Donath-Landsteiner Ab 🛡️🎯
paroxysmal COLD hemolysis 🎯
biphasic IgG 🛡️🎯
post-URI ❄️