Biochemistry — ATP Depletion

⚡ Low Energy State

When ATP runs out, cells start dying in tissue-specific ways. Each deep dive below covers how a different organ system handles energy failure — what breaks first, what's reversible, and the high-yield board distinctions.

🔬
Core Concepts
The universal ATP depletion cascade. Na/K pump failure, calcium influx, mitochondrial damage. Reversible vs irreversible injury markers.
🧬
Breast & Marrow
Fat necrosis in breast tissue, marrow infarction in sickle cell. How high metabolic demand meets poor collateral circulation.
🌱
Repro, Endo & Marrow
Ovarian torsion, adrenal crisis, bone marrow aplasia. Hormone-dependent tissues and the consequences of ischemia.
🌀
Respiratory & Renal
ATN vs cortical necrosis, pulmonary infarction. Why kidneys get ATN first and lungs resist infarction (dual blood supply).
🩸
Vessels, Bladder & Uterus
Three rapidly dividing cell lines that fail when ATP drops. Endothelium, urothelium, and endometrium — from petechiae to secondary amenorrhea to sterility.